Wednesday, October 30, 2013

SYSTEMIC LUPUS ERYTHEMATOUS Part 1


SYSTEMIC LUPUS ERYTHEMATOUS
Definition
Lupus :
- autoimmune diseases
- Acute and chronic
- multisystem
- there is some form of clinical :
  1. systemic (SLE), 
  2. discoid (DLE, scarring rash only),
  3. drug-induced (DILE),
  4. neonatal (NLE).
General :
  • autoimmune multisystem disease
  • prevalence 1 in 2,000
  • 9 to 1; female to male (1 in 700)
  • peak age 15-25
  • immune complex deposition
  • photosensitive skin eruptions, serositis, pneumonitis, myocarditis, nephritis, CNS involvemen
The incidence
  • > ratio of 9:1, age 15-45 years
  • black> white
  • Surve IN USA à 1,500,000 people
  • Chronic inflammatory factors trigger yet dikeyahui responsesà
  • SLE: results of a complex interaction between genetic and environmental factors
  • Environmental factors: infections, antibiotics, ultraviolet light, extreme stress, certain drugs, hormones
  • certain drugs suspected drug activity meningkarkan immune response or reduce the immune response procainamide, hydrazaline,

1 comment:

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