Wednesday, October 30, 2013

SYSTEMIC LUPUS ERYTHEMATOUS part 2

SYSTEMIC LUPUS ERYTHEMATOUS part 2


  • autoimmune ? antibody fails to recognize the body's own cells
  • As a result ? caused inflammation in the body
  • In systemic lupus arise keradangannya
  • Antibodies are found : ANA , ds DNA , anti- Ro , anti- La , and anti- RNP .
Systemic Lupus Erythematosus

Mechanisms of autoantibody production in SLE ​​and APS 

Mechanisms of renal damage by anti - DNA antibodies

Classic picture :
-          young woman ,
-          fever ,
-          buterfly rash,
-          lymphadenopaty ,
-          joint pain ,
-          alopecia ,
-          pleural effusion ,
-          edema + Uriah protein

Not all patients gave a clear clinical picture , sometimes only one or two symptoms for months , and then the other symptoms are more obvious

Non-specific symptoms
At first the symptoms that usually preceded by non-specific
  • fever
  • nausea
  • Vomiting
  • appetite down
  • Weight loss
  • Fast tired
Results: Sle patients who are hospitalized in Soetomo april - september 2003 ( 98 patients )
Weight down
67.3
Tired
84.7
fever
53


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