SYSTEMIC LUPUS ERYTHEMATOUS
Definition
Lupus :
- autoimmune
diseases
- Acute
and chronic
- multisystem
- there
is some form of clinical :
- systemic (SLE),
- discoid (DLE, scarring rash only),
- drug-induced (DILE),
- neonatal (NLE).
General :
- autoimmune multisystem disease
- prevalence 1 in 2,000
- 9 to 1; female to male (1 in 700)
- peak age 15-25
- immune complex deposition
- photosensitive skin eruptions, serositis, pneumonitis, myocarditis, nephritis, CNS involvemen
The incidence
- ♀> ♂ ratio of 9:1, age 15-45 years
- black> white
- Surve IN USA à 1,500,000 people
- Chronic inflammatory factors trigger yet dikeyahui responsesà
- SLE: results of a complex interaction between genetic and environmental factors
- Environmental factors: infections, antibiotics, ultraviolet light, extreme stress, certain drugs, hormones
- certain drugs suspected drug activity meningkarkan immune response or reduce the immune response procainamide, hydrazaline,
