SEBORRHEIC KERATOSIS
and EPIDERMAL NEVUS
SEBORRHEIC KERATOSIS
- Seborrheic Keratosis is the most common benign epidermal tumor.
- Usually begin as wwll-circumscribed, dull, flat, tan, or brown patches with pseudohom cysts
- Rapidly-growing, symptomatic, or atypical lesions should be biopsied to rule uot malignancy such as basal cell carcinoma, or melanoma.
- Clinical and histopathologic variants include the common seborrheic keratosis, reticulated seborrheic keratosis, stucco keratosis, clonal seborrheic keratosis, irritated seborrheic keratosis, seborrheic keratosis with squamous atypia, melanoacanthoma, and dermatosis papulosa nigra.
- Hallmark histopathologic findings : Acanthosis, papillomatosis, pseudohorn cysts, hyperkeratosis
- Internal malignancy : Individuals can develop multiple, eruptive seborrheic keratosis (leser-Trelat sign). Adenocarcinoma of the stomach is most common associated malignancy.
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EPIDERMAL
NEVUS
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