CHLAMYDIA TRACHOMATIS

CHLAMYDIA TRACHOMATIS

Chlamydia trachomatis consists of 15 serovars :
• A, B, Ba, C: causes trachoma
• D, E, F, G, H, I, J, K: causes of genital tract infections, conjungtivitis, infantile pneumonia
• L1, L2, L3, causes LGV (lymphogranuloma venereum)

Epidemiology :
• Th. 1997:> 500,000 cases (200/100.000 population)
• United States: 3-4 million cases / year
• WHO: 90 million cases

Cause :
Chlamydia trachomatis serovar D, E, F, G, H, I, J
• Have a cell wall and cell membrane
• The cytoplasm containing DNA and RNA
• Multiplication only on cells (obligate intracellular)
• Establish inclusions in the cytoplasm
• Antigen: MOMP (major outer membrane protein), lipopolysaccharide, HSP (heat shock protein)
• Causing the immune response: the formation of antibodies and cellular immunity

Chlamydia Trachomatis
Process of entry into the cell :
1. Elementari inherent in the cell body
2. Entry into the cell
3. Berfubah be retikulate body (grow and reproduce)
4. Transformed into the body Elementari
5. Released to infect.

Chlamydia Infection In Men
• Symptomatic: 25% of cases
• milder symptoms of gonorrhea
   - Urethral discharge
   - Dysuria
   - Epididymitis
   - Prostatitis.
• Can cause infertility
• Incubation :7-21 days

Other Forms Clinic
• Epididymitis
• Prostatitis
• proctitis
• Reiter syndrome

Sal Genital Chlamydia Infection In Women
• Asymptomatic: 60-80%
• Symptoms:
   - Purulent vaginal discharge
   - Servicitis mukopurulen
   - Lower abdominal pain
   - Post coital / intermenstrual bleeding
   - Dysuria
   - Pelvic inflammatory disease (PID)
• Can lead to extra uterine pregnancy, infertility, cervical atypia Celluler

Cervicitis
• Striking a cylindrical cervical epithelial
• It is difficult to distinguish from other processes in the cervix inflammasi
• Symptoms:
   - Discharge mukopurulent
   - Hypertrophic Ectopia
   - Postcoital bleeding
   - spotting
• Criteria alleged cervicitis:
   - Cervical smear PMN> 15 PLP
   - Erythema, edema, bleeding easily
• C. trachomatis serotype G could develop into SCC

Other Clinical Forms
• Bartholinitis
• Endometritis
• salpingitis
• perihepatitis

Laboratory Examination Of Chlamydia Infection
Detection of Chlamydia :
• Cell culture
• DFA (Direct Fluorescent Antibody Assays)
• EIA (Enzyme Immunoassays)
• hybridzation RNA-DNA (PCR and LCR)

Serology :
• Microimmunofluorescence (MIF)
• ELISA (Enzyme-lnked immunosorbent assay) IgM, IgA, IgG

Treatment :
• Doxycycline 2 x100 mg for 7-10 days
• Erytromisin 2 g / day for 7-10 days
• Azithoromycin 1000 mg single dose