PEDIATRIC INFECTIOUS DISEASES

PEDIATRIC INFECTIOUS DISEASES

• Infection is an attempt organism to survive
   - Virus without cytoplasm, must enter into another cell
   - Germs go into organ
   - Parasites / worms in the gut / blood
• Victory is temporary: the change is lasting: adaptation and mutation, addition and deletion
• supportive climate throughout the year
• Eradication of mosquitoes is against nature

Pyramid of infection and illness prevention

 

ENVIRONMENT
Tropical belt full environmental battle of life,
deprived of food, both carbohydrate and protein.
Population density and environmental pressures
"Rapid population growth and very greedy for natural resources, causing changes in the chemical and biological balance of the world"

Violation of the rules of health and hygiene sanitation
• Uncontrolled urbanization
   - Displacement (displaced) due to rapid population disaster
   - Causing density and density and trigger lack shelter, water, sewage
• Cause the more rapid transmission of the disease

GERM
Germs that cause infections should have the ability to:
• Perform invasion
• Multiplication
• Transmission to another individual

• Germs are designed to survive in extreme conditions, is able to live
   - Up to 10,000 m in the soil
   - A few thousand feet in the air
   - In a volcano
   - In the dust spores of Cl. tetani
• In the human body there are cells prokaryotik 10 more than the cell Eukaryotic Structural

HOST
• healthy and strong is not enough
• Infants not done developing immune system
• The child became ill ok :
   - Virus / germs enter the body
   - Environmental influences (transmission / pollution)
   - Is not immune to infectious diseases
• The anti-immunization

PATHOGENESIS OF INFECTION
• Adhesion and entry of germs
• Invasion of bacteria, phagocytic cells attack germs and replies
• The spread of germs
• The immune response to infection
• Strategy germs faces an immune response
• The mechanism of cell damage
• Healing infection
• Failure elimination of germs
• bacteria and host factors affecting susceptibility

DISTRIBUTION / TRANSMISSION GERM
horizontal, through air, water, food, vector
vertical, mother to the baby through the placenta, breast milk

ENTRY PROCESS (INVASION) GERM
• Attached to the epithelium, eyes, wounds etc.
• Stick to the opening was
• Stick to the existing specific receptors (trophisme)
• Puncture, skin damage, epithelial
• Causes inflammation
• direct entry

COLONIZATION AFTER ADHESION :
• Growing in epithelial cells
• Food for germs:
- Iron
- Tryptophan
• Invasion of subepithelial
- Through the basement membrane
- Intercepted 3 types of the body's defense: tissue fluid, phagocytic cells, lymph
• Germs intracellular
- Spread throughout the body. pb as germs enter the blood in the mobile blood cells
- Unable to replicasi up in the target organ, can be dormant

 

GROWTH GERM IN THE EPITHELIUM
• Viral infections respiratoir,
• biofilms, EFL (epithelial lining fluid)
• Not going viral invasion to underlying tissue,
• nonimunologi factor (innate immunity / physical barrier)
• stop infection

INVASION OF SUB-EPITHELIAL
• Occurs due to EFL or damaged epithelial cells
• invasion into
• detained epithelial basal membrane as filter
• membranes damaged by inflammation and cell damage
• held a germ invasion of sub-epithelial tissue

IN SUB - EPITHELIAL GERM FACING 3 SYSTEM
1. fluid Network

• Contains plasma proteins including immunoglobulins
• Is a bacteria culture media
• Germs multiplication, encouraging a variety of products, triggered inflammatory response
• There are many more, complement, other serum factors (nature antikuman)
• Contains anti-bacterial ingredient of platelets, PMN, macrophages

2. Lymph system
3. cells Phagocytes


Phagocytosis, endocytosis and fagolisosom in macrophages

SPREAD OF GERMS
1. Login lymph channels - kel lymph
2. kel lymph:
    - filter
    - Where the immune system works
3. Not being able to block, it spread
4. Directly enter the blood vessels lewt lymph channels
5. Issuing materials, staged deployment

INFECTION CURE
Multiplication of germs in the stop
1. germs are not spread
2. reduced the number of germs
3. germs dead. Furthermore:
 
Tidying up damaged tissue
• cleaning up germs
• smoothed
• reconstruction
• recover